Abstracts - conferences
Paris - Wednesday Nov. the 2nd, 2022
• 9:00 - 9H30 - Welcome - (including introductory remarks [2]) Alexis Brice (CEO of Paris Brain Institute) - Bruno Dubois
• 9:30 - 10H10 - • The prefrontal cortex : from monkey to man - Speaker : Richard Levy (Paris, France) (Session Moderator : Bruno Dubois)
• 10:10 - 10H50 - • Disinhibition : What it is ? - Speaker :Kate Rankin (San Francisco, USA) (Session Moderator : Lara Migliaccio)
• 11:05 - 11H45 - • Apathy and Motivation in neurodegenerative diseases - Speaker : Masud Husain (Oxford, UK) (Session moderator : Richard Levy)
• 11:45 - 12H30 - • Creativity and the frontal lobes : from normal to pathology
- Speakers : Leonardo de Souza (Belo Horizonte, Brazil) and Emmanuelle Volle (Paris, France) (Session moderator : Kate Rankin)
• 13:30 - 14H10 - • “The von Economo neurons and higher-level cognition : from normal to disease
- Speaker: William Seeley (San Francisco, USA) (Session Moderator: Yolande Pijnenburg)
• 14:10 - 14H50 - • Personality trait, psychiatric disease, and FTD : a clinico-genetic continuum?
- Speaker : Yolande Pijnenburg (Amsterdam, The Netherlands) (Session moderator : Dario Saracino)
• 15:05 - 16H15 - • Panel discussion : How to define the preclinical and the prodromal stages, and when does the disease begin ? (criteriology of the presymptomatic FTD)
• Panel Discussion
Speakers : Speakers : Barbara Borroni (Brescia, Italy ): Criteria/Definition of preclinic & prodromal phases
Yolande Pijnenburg (Amsterdam, The Netherlands) : Behavior
Jonathan Rohrer (London, UK): Neuroimaging
John van Swieten (Rotterdam, the Netherlands): Biomarkers
(Session moderators : Isabelle Le Ber / Lara Migliaccio)
• Closing remarks & end
Lille - Thursday Nov. 03, 2022
• 9:00 - 9:30 - Lecture : Ménage à Trois: Temporal Pole, Word Comprehension, and TDP-C
Marsel M. Mesulam (United States)
• 9:45 - 11:45 - • Early clinical markers : Olivier Piguet (Australia) (15 min)
• Right temporal variant frontotemporal dementia :
Hulya Ulugut Erkoyun (Netherlands) (15 min)
• International network on PSP/CBD research : Guenter Hoglinger (Germany) (15 min)
• Clinical and pathologic features of cognitive-predominant corticobasal degeneration :
Nobutaka Sakae (Japan) (15 min)
• It’s not what you say, it’s how you say it: the impact of FTD on visual analogue scales
Rebecca Williams (United Kidom) (10 min)
• Disease progression models in an international familial frontotemporal dementia cohort reveal the temporal ordering
of clinical and biomarker changes and inform clinical trial design
Adam Staffaroni (United States) (10 min)
• Exploring potential markers of pre-dementia risk states in motor neuron diseases: a longitudinal study of Mild Behavioral Impairment
and its relation to cognition
Pilar Maria Ferraro (Italy) (10 min) - Q & A, All Speakers (30 mn)
• 13:30 - 15:05 - • Neurofilaments as prognostic and stratification biomarkers in FTLD :
Dario Saracino (France) (15 min)
• Molecular mechanisms and biomarkers in frontotemporal dementia :
Annakaisa Haapasalo (Finland) (15 min)
• Importance of fluid biomarkers in the diagnosis of FTD :
Harro Seelaar (Netherlands) (15 min)
• Prosaposin: a lysosomal CSF biomarker of progranulin-associated frontotemporal dementia
Imogen Swift (UK) (10 min)
• Distinguishing FTLD-tau from FTLD-TDP using plasma GFAP : NfL
Katheryn Cousins (US) (10 min) - Q & A, All Speakers (30 mn)
• 15:40 - 17:30 - Lecture : Promises and pitfalls of Alzheimer’s biomarkers in patients with FTD syndromes :
Renaud La Joie (United States) (25 min)
• MRI in frontotemporal dementia : state of the art, promises and challenges :
Federica Agosta (Italy) (15 min)
• PET imaging of synaptic health in syndromes associated with frontotemporal lobar
degeneration : Maura Malpetti (United Kingdom) (15 min)
• Modeling disease progression in genetic frontotemporal dementia :
Esther Bron (Netherlands) (15 min)
• Progression of MRI and neuropsychiatric changes in predementia frontotemporal dementia mutation carriers with TMEM106B genetic variants
Hyunwoo Lee (Canada) (10 min)
• Radiogenomics of C9orf72 expansion carriers reveals global transposable element de-repression and enables prediction of thalamic atrophy and clinical impairment
Jennifer S. Yokoyama (United States) (10 min) - Q & A, All Speakers (30 mn)
• 17:30 - 18:20 - • Memory Impairment in Frontotemporal Dementia :
Bradley Boeve (United States) (15 min)
• Right anterior temporal degeneration and loss of socioemotional semantics: The semantic behavioral variant frontotemporal dementia
Kyan Younes (United States) (10 min)
• Correlation of 4 behavioural profiles and the underlying pathology in Fronto-temporal Dementia
Grâce François (France) (10 min) - Q & A, All Speakers (30 mn)
• 18:20 - 18:45 - • Lecture : New genes (since 2020) in FTD and their clinical features : Cyril Pottier (United States) (25 min)
Lille - Friday Nov. 04, 2022
• 8:00 - 8:25 - Lecture : Data from the FRONTotemporal dementia Incidence European Research Study’ : Giancarlo Logroscino (Italy)
• 8:25 - 8:50 - Lecture : Anatomical correlates of social cognition in patients with the behavioral variant
frontotemporal dementia Sandra Baez (Colombia)
• 8:50 - 9:15 - Lecture : COVID-19 and Dementia : Challenges and opportunities for reframing care
Suvarna Alladi (India)
• 9:45 - 11:30 - • From Neurodevelopment to Neurodegeneration: Clues from Genetic FTD :
Elizabeth Finger (Canada) (15 min)
• Disparate cellular networks of tau vs TDP-43 proteinopathies in
frontotemporal dementia : David Irwin (United States) (15 min)
• Structures of pathological TDP-43 filaments in human neurodegenerative
disease : Benjamin Ryskeldi-Falcon (United Kingdom)
• Co-existing proteinopathies in globular glial tauopathy Shelley Forrest (Australia) (10 min)
• To split or not to split: data-driven components along the PPAOS-PAA spectrum
Ignacio Illan-Gala (Spain) (10 min)
• FTLD-TDP targets brain regions enriched for recently evolved genes regulated by TDP-43
Lorenzo Pasquini (United States) (10 min) - Q & A, All Speakers (30 mn)
• 13:45 - 15:50 - • Need to be confirmed (15 min)
• The immune system in Frontotemporal lobar degeneration with tau :
Delphine Boche (United Kingdom) (15 min)
• Loss of function splicing : Pietro Fratta (United Kingdom) (15 min)
• The Autophagy / Lysosomal Pathway in FTD : Li Gan (United States) (15 min)
• Speakers selected on abstracts (4x10 min) Round table (30 min)
• 17:00 - 18:30 - • Clinical and pathological aspects of FTLD-FUS and FET proteinopathies :
Ian Mackenzie (Canada) (15 min)
• Investigating a role for progranulin in PINK1/Parkin mitophagy using induced
pluripotent stem cells : Selina Wray (United Kigdom) (15 min)
• IGranulins are the functional units of progranulin and are neuroprotective
Thomas Kukar (United States) (10 min)
• Investigating the ability of granulin subunits to rescue lysosome dysfunction, inflammation, and neurodegeneration in a mouse model of frontotemporal dementia
Jessica Root (United States) (10 min) - Q & A, All Speakers (30 mn)
• 18:30 - 19:00 - Lecture : Molecular basis of glial pathologies in FTLD : Eric Huang (United States) (30 min)
Lille - Saturday Nov. 05, 2022
• 8:00 - 8:30 - Lecture : Interface between psychiatric diseases and FTD Simon Ducharme (Canada)
• 8:30 - 9:35 - • Psychosis in Neurodegenerative Disease : Associations with Structural Brain Networks and Neuropathology :
Katherine Rankin (United States) (15 min)
• Apathy, empathy and depression in behavioural-variant frontotemporal dementia and Alzheimer’s disease: Are we talking about the same thing?
Halle Quang (Australia) (10 min)
• Evidence for an attentional theory of hallucination generation in Frontotemporal Dementia – a cognitive, behavioural and neuroimaging study
Emma Devenney (Australia) (10 min) - Q & A, All Speakers (30 mn)
• 10:05 - 11:50 - Lecture : Neurocognitive allostatic interoception in neurodegenerative diseases (25 min)
Agustin Ibanez (Argentina)
• Social cognition assessment in mild neurocognitive disorder: a joint effort of the SIGNATURE consortium: Alessandra Dodich & Chiara Cerami (Italy)
• The application of the mini-SEA in clinical diagnostics : Maxime Bertoux (France) (15 min)
• Primary Progressive Aphasia (PPA): Northwestern Anagram Test (NAT) :
Sandra Weintraub (United States) (15 min)
• Primary Progressive Aphasia (PPA): Northwestern Anagram Test (NAT) :
Sandra Weintraub (United States) (15 min)
• Lexical tone impairment in Chinese-speaking individuals with primary progressive aphasia Boon Lead Tee (United States) (10 min)
• Processing of acoustically degraded speech in primary progressive aphasia and Alzheimer’s disease
Jess Jiang (United Kingdom) (10 min) - Q & A, All Speakers (30 mn)
• 14:45 - 16:15 - • Communication and Quality of Life Interventions for PPA: Where are we now? :
Emily Roglaski (United States) (15 min)
• Therapeutic Development for Frontotemporal Degeneration : Adam Boxer (United States) (15 min)
• Transcranial direct current stimulation for language improvement: pre-therapeutic outcomes in semantic dementia, FTD and PSP Marc Teichmann (France) (10 min)
• Immediate and long-term benefits of restitutive treatment for speech and language in primary progressive aphasia Maya Henry (United States) (10 min)
• Targeting pathological transcriptional variants in C9orf72-associated frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS): Results from the FOCUS-C9 clinical trial
Jonathan Rohrer (United Kingdom) (10 min)
Q & A, All Speakers (30 mn)
• 16:15 - 17:00 - • Consortia : GENFI Jonathan Rohrer (United Kingdom) (10 min), ALL FTD Howie Rosen (10 min), ROUND TABLE (15 min)
Lille - Friday Nov. 04, 2022
Caregiver day
• 9:45 - 11:00 - • Opening address Florence Pasquier & Dominique de Blanchard (France) (5 min)
• Overview of the FTD spectrum disorders - Behavioral variants - Diagnostic processe Janine Diehl-Schmid (Germany) & Yolande Pijnenburg (the Netherlands) (25 min + 10 min questions)
• What are the contributions of biomarkers (imaging, blood, CSF,…) & Role of brain and tissue donation Vincent Deramecourt (France) (10 min + 10 min questions)
• Genetic in FTD Caroline Greaves (United Kingdom) (10 min + 5 min questions)
• 11:00 - 11:30 - • Nothing about us without us: giving voice to persons with a diagnosis, family members and care partners through research participation Kathie Brandt (United States)
(10 min + 5 min questions)
• Results of the Better Conversations with Primary Progressive Aphasia (BCPPA) pilot-feasibility trial: Communication Partner Training to keep families together Anna Volkmer (United Kingdom) (10 min + 5 min questions)
• 13:45 - 15:35 - • Baluchonage D. de Blanchard (France) (10 min)
• Patient Therapeutic Education Florence Lebert (France) (10 min)
• Support and respite platforms for family caregivers L. Forster (France) (10 min)
• Fondation Alzheimer (France) (5 min)
• France Alzheimer (France) (5 min)
• Caring for caregiver : the experience of Aimft, the Italian Association of Frontotemporal Disease Laura Invernizzi (Italy) (10 min)
• Local experiences in supporting caregivers in the USA Sharon Denny (United States) (10 min)
• Domestic violence in FTD Emmanuel Cognat (France) (10 min)
• Accompanying the children of person with dementia Helga Schneider-Schelte (Germany) (10 min)
• Q & A, all speakers (30 min)
• 16h35 - 17h:35 - • Creative workshop to express the feelings of patients and relatives by
Carl Cordonnier (France) (10 min)
• Testimony of D. Delatte (France) (10 min)
• Testimony of A. C. Ospina (France) (10 min)
• Advance care planning and medical decision-making in the era of COVID-19: use of video tools for guiding dementia caregivers Bonnie Wong (United States) (10 min + 5 min questions)
• A prospective study of criminal risk behaviours in frontotemporal dementia
Fiona Kumfor (Australia) (10 min + 5 min questions)